Dr. Jarle Bruun’s research profiled in the 2016 National report from the Regional Health Authorities

The report highlights clinically relevant research, and projects ongoing in the K.G. Jebsen Colorectal Cancer Research Centre were selected from the South-Eastern Norway Regional Health Authority. Specifically, Dr. Jarle Bruun's paper identifying the gene Regulator of Chromosome Condensation 2 (RCC2) as functionally important in colorectal cancer, and furthermore that changes of RCC2 at the DNA and protein level can identify clinically distinct subgroups of patients with inferior survival.

Epigenetic markers stratify colorectal cancer patients within a genetically defined poor prognostic patient group

Vedeld and co-workers show that the CpG Island Methylator Phenotype (CIMP) carry prognostic value across stages. Patients with microsatellite stable tumors with BRAF V600E mutations, defining a poor prognostic subgroup, can be further subdivided by the CIMP status. This is a study from the Lind and Lothe groups in collaboration with the clinical research team of Arild Nesbakken.

Latest publications

Landskron J et al. 2017. C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. PLoS One. 2017 Jul 31;12(7):e0182030. Ommundsen N et al. 2017. Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer. A randomised controlled trial. Colorectal Dis. 2017 Jun 26. [Epub ahead of print] Lind GE et al. 2017. Details matter: the role of genomic location and assay standardization in DNA methylation analyses. Epigenomics. 2017 Jul;9(7):933-935. Garborg K et al. 2017. Quality Indicators in Colonoscopy. Curr Treat Options Gastroenterol. 2017 Jul 12. [Epub ahead of print] Totland MZ et al. 2017. E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin43 to promote loss of gap junctions. J Cell Sci. 2017 Jul 21. [Epub ahead of print] All publications