Two new academic degrees digitally defended at University of Oslo, by members of the K. G. Jebsen Colorectal Cancer Research Centre

In June, Tuva Høst Brunsell (MD) defended her PhD "Heterogeneity of prognostic biomarkers in colorectal liver metastases", Institute for Clinical Medicine, Faculty of Medicine, University of Oslo. The thesis includes three papers (Brunsell et al., Clin Colorectal Cancer 2020; Brunsell et al., Eur J Surg Oncol 2019; Berg*, Brunsell* et al., submitted). On September the 4th, Christer Anker Andreassen, defended his MSc, Institute of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. "The functional and clinical impact of the E3 Ubiquitin ligase NEDD4 in colorectal cancer and its role in regulating PTEN and P53".

TP53 proficient colorectal cancer cells are sensitive to PARP inhibition

By examining vulnerabilities in colorectal cancer, Jørgen Smeby, Kushtrim Kryeziu, and colleagues demonstrated the efficacy of PARP inhibitors for a subgroup of colorectal cancer cell lines in a recent paper in EBioMedicine (The Lancet’s open access).

Latest publications

Berg et al. 2020. Genomic and prognostic heterogeneity among RAS/BRAFV600E /TP53 co-mutated resectable colorectal liver metastases. Mol Oncol [Epub ahead of print] Flatin et al. 2020. Multiregional assessment of CIMP in primary colorectal cancers: phenotype concordance but marker variability. Int J Cancer [Epub ahead of print] Pilleron et al. 2020. Age disparities in stage-specific colon cancer survival across seven countries: an ICBP SURVMARK-2 population-based study. Int J Cancer [Epub ahead of print] Bergsland et al. 2020. Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer. ESMO Open 5(6): e001040 Smeby et al. 2020. Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity. EBioMedicine 59: 102923 All publications