Two new academic degrees digitally defended at University of Oslo, by members of the K. G. Jebsen Colorectal Cancer Research Centre

In June, Tuva Høst Brunsell (MD) defended her PhD "Heterogeneity of prognostic biomarkers in colorectal liver metastases", Institute for Clinical Medicine, Faculty of Medicine, University of Oslo. The thesis includes three papers (Brunsell et al., Clin Colorectal Cancer 2020; Brunsell et al., Eur J Surg Oncol 2019; Berg*, Brunsell* et al., submitted). On September the 4th, Christer Anker Andreassen, defended his MSc, Institute of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. "The functional and clinical impact of the E3 Ubiquitin ligase NEDD4 in colorectal cancer and its role in regulating PTEN and P53".

TP53 proficient colorectal cancer cells are sensitive to PARP inhibition

By examining vulnerabilities in colorectal cancer, Jørgen Smeby, Kushtrim Kryeziu, and colleagues demonstrated the efficacy of PARP inhibitors for a subgroup of colorectal cancer cell lines in a recent paper in EBioMedicine (The Lancet’s open access).

Latest publications

Smeby et al. 2020. Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity. EBioMedicine 59: 102923 Eilertsen et al. 2020. Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer. Cancer Lett. 469: 246-255 Araghi et al. 2020. Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project). Gut gutjnl-2020-320625 Lopes et al. 2020. A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis. Gastric Cancer 23: 811-823 Bruun et al. 2020. Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity. Clin. Cancer Res. 26: 4107-4119 All publications