Article on colorectal cancer in BBA – Reviews on Cancer

In January 2015, "Portrait of the PI3K/AKT pathway in colorectal cancer" authored by researchers at the K.G Jebsen Colorectal Cancer Research Centre was published in the journal Biochimica et Biophysica Acta (BBA) – Reviews on Cancer.

First authors Stine A. Danielsen and Peter Eide. Photo: Jarle Bruun

Portrait of the PI3K/AKT pathway in colorectal cancer

Cells sense, integrate information and communicate through molecular signaling networks. Within these networks, the PI3K/AKT pathway plays a critical role in controlling cell proliferation, differentiation and death. PI3K/AKT hyper-activation is observed with considerable frequency across many cancer types and is thus an attractive target for pharmacological inhibition. In their article, Danielsen, Eide and colleagues review PI3K/AKT aberrations at multiple molecular levels in colorectal cancer and summarize the influences specific changes might have on the patients’ prognosis and response to targeting therapy.